I've been playing guitar for over half of my life at this point, and I still love to try new things - new pickups, new amps, new strings, new picks...you get the idea. Of all the things to try out on a guitar, one of the easiest is a new tuning. Assuming you have a set of strings that can handle the tuning you're looking to check out (I wouldn't, for example, suggest trying out Drop A with a 10-46 set), it's pretty much just a task of tuning up the guitar and seeing how you feel about it before actually committing and doing a full setup.