I first played Cipher Prime's Splice when it was part of a recent fourth Humble Bundle, and it still enjoys a place in my Installed Games list on Steam. It's a puzzle game that involves taking different strains of bacteria and "splicing" them, moving around cells in order to fit an provided outline. Of course, you have a set amount of moves, and added "mutation" cells will change the game in different ways: for instance, one mutation will cause each cell attached to it to grow, or split identically. The trick is to plan ahead and think strategically in order to finish each level and move on.
If you're a fan of abstract puzzle games, then Cipher Studios' Splice should pique your interests. The entire game takes place under the microscope, where it's your job to re-arrange and splice together strands of DNA (hence the name of the game). Each cell will react differently to different splices, so it's up to you to figure out how to successfully restructure each strand and completely the sequence.
The game features over 75 different puzzles, each of which contain a limited number of splices in order to complete. For replayability, each level also has an angelic solution, where the sequence is solved in only a few splices.